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MLB Parlay Picks for June 4: Nationals on the Moneyline vs the Cubs at Home 4hb60

Astros to Win Against Pirates 5y5yo

SportsHandle StaffSportsHandle Staff
June 4, 2025
in Sports

Baseball Betting (Aaron Doster-USA TODAY Sports) h2wj

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While waiting for the weekend action to start, we have some prized mid-week MLB parlay picks to get you going. The Chicago Cubs, 8-2 in their last ten, want to extend their winning streak by facing the Washington Nationals. The American League West top team, the Houston Astros, travels to Pittsburgh in a cross-conference matchup versus the Pirates. 

Sparks will also fly in the Baltimore Orioles vs. Seattle Mariners American League matchup, and we have everything covered as we have prepared all the tips that you could possibly need for these games. If you’re looking to add a bonus to your bets this week, there’s a BetMGM promo available that lets new s claim up to $150 in bonus bets on MLB games like Orioles vs. Mariners.

Game Date Tip Alternative Bet
Chicago Cubs vs. Washington Nationals Wednesday, June 4 Nationals on the Moneyline Over 8.5 Runs
Houston Astros vs. Pittsburgh Pirates Wednesday, June 4 Astros on the Moneyline Under 9 Runs
Baltimore Orioles vs. Seattle Mariners Wednesday, June 4 Mariners on the Moneyline Over 8.5 Runs
Cleveland Guardians vs. New York Yankees Wednesday, June 4 Yankees on the Moneyline Under 9 Runs
Kansas City Royals vs. St. Louis Cardinals Wednesday, June 4 Royals on the Moneyline Over 8.5 Runs

*Sports betting carries inherent risks, and outcomes can be unpredictable. The recommendations offered here are based on current data and analysis but should not be viewed as guarantees of success.

Chicago Cubs vs. Washington Nationals – Nationals on the Moneyline 3no15

The Chicago Cubs travel to Nationals Park to face the Washington Nationals on Wednesday. The Cubs, sitting at 38-22 and leading the NL Central, come in as -140 favorites, while the Nationals, at 28-32, are slight underdogs at +118. On the mound, Chicago sends lefty Matthew Boyd (5-2, 3.08 ERA), while Washington counters with MacKenzie Gore (2-5, 3.16 ERA). Gore has pitched especially well at home, posting a 2.64 ERA and holding opponents to a .165 average in D.C..

Chicago’s offense has been among the league’s best. But they may be without star outfielder Kyle Tucker, who is listed as day-to-day. The Nationals, meanwhile, have been hitting well lately and are 4-2 in their last six games. Both teams have seen some success against the opposing starter in limited at-bats, and Washington’s bullpen has struggled, ranking 28th in ERA.

Consider taking the Nationals moneyline at plus odds, given Gore’s strong home numbers and the Cubs’ potential lineup concerns. The over 8.5 runs is also worth a look, as both teams have shown they can score and both bullpens have been inconsistent lately.

Houston Astros vs. Pittsburgh Pirates – Astros on the Moneyline d5n2z

The Houston Astros travel to PNC Park to face the Pirates. Houston enters as the favorite, listed around -136 to -140 on the moneyline, while the Pirates are home underdogs at +116 to +118. The Astros will start rookie right-hander Ryan Gusto (3-2, 4.62 ERA), while the Pirates counter with rookie Mike Burrows (0-1, 8.64 ERA).

Houston has momentum, coming off a shutout win and winning seven of their last nine games. Jeremy Peña continues to be a key contributor, leading the Astros in average and hits. The Pirates, meanwhile, have struggled to score and have been shut out ten times in 61 games this season. Their lineup will need to step up to Burrows, who has had a tough start to his MLB career.

The main betting tip is taking the Astros at moneyline (-136), which is a solid pick. Houston has performed well as a favorite this season, winning 55% of such games, and the pitching matchup favors them against a struggling Pirates offense. But also consider the under 9 runs (-115). Both teams have shown a tendency for lower-scoring games, and the Pirates have struggled to put up runs against quality pitching

Baltimore Orioles vs. Seattle Mariners – Mariners on the Moneyline 14d1i

An intriguing matchup is expected between the Baltimore Orioles and Seattle Mariners, as they continue their series at T-Mobile Park. Both teams are sending young right-handers to the mound, Cade Povich (1-4, 5.29 ERA) for Baltimore and Emerson Hancock (2-2, 5.64 ERA) for Seattle. Seattle enters as the slight favorite at home, listed at -132 on the moneyline, with Baltimore at +111. The over/under is set at 8.5 runs, reflecting the potential for some offense given both starters’ elevated ERAs.

Seattle has won just over half of its games as a favorite this season and has a 14-12 record when favored by similar odds. Baltimore has struggled as an underdog, with only two wins in their last nine games when listed at +112 or longer. The Mariners’ offense will look to rebound after managing only one run in the previous matchup, while Baltimore’s Colton Cowser remains a player to watch after homering in his return from injury.

I would say take the Mariners on the moneyline (-132). Seattle has a slight edge at home and faces a Baltimore team that has not performed well as an underdog this season. Alternatively, consider the over 8.5 runs. Both starting pitchers have ERAs above 5.00, suggesting that runs could come in bunches for both sides.

Cleveland Guardians vs. New York Yankees – Yankees on the Moneyline 5o3h7

The Cleveland Guardians visit Yankee Stadium on June 4 to face the home New York Yankees. The matchup pits Guardians starter Luis Ortiz against the Yankees’ lineup led by Aaron Judge. New York enters as the favorite with a moneyline of -187, while Cleveland is the underdog at +155. The total runs line is set at 9, with the Yankees favored on the run line (-1.5) at +109 odds.

The Yankees boast a strong home record and have won 66.7% of games as favorites this season. Aaron Judge continues to be a dominant force, hitting .391 with 21 home runs and is expected to drive in runs against the Guardians’ pitching. Cleveland has struggled as underdogs of +155 or worse, yet they have shown resilience, winning nearly half of their games as underdogs overall.

Consider taking the Yankees on the moneyline (-187) given their strong home performance and offensive firepower, especially with Judge in form. The under 9 runs total is also a solid option. Both teams have shown tendencies toward lower-scoring games in recent matchups, and the pitching matchup suggests a tighter game.

Kansas City Royals vs. St. Louis Cardinals – Royals on the Moneyline 1w2r2u

The Kansas City Royals visit Busch Stadium to face the St. Louis Cardinals in the second game of their series. The Cardinals, holding a 33-27 record and a strong 19-9 at home, are slight favorites with -131 odds, while the Royals stand at 32-29 overall and 13-16 on the road with +110 odds. The first game was a tight 1-0 win for the Royals, and the series is currently tied 2-2 on the season between these rivals.

Starting pitchers are Miles Mikolas for the Cardinals (4-2, 3.90 ERA) and Noah Cameron for the Royals (2-1, 1.05 ERA). The Cardinals rank third in MLB with a .259 team batting average, while the Royals hold seventh in the American League with .248. Key players include Nolan Arenado for St. Louis and Vinnie Pasquantino for Kansas City, who leads the Royals with eight home runs.

Take the Royals on the moneyline at +110. Despite being underdogs, Kansas City has a solid recent record against the Cardinals in St. Louis (3-0) and could extend their series lead. But also consider the over 8.5 runs total. Their recent matchups have seen a mix of low and high-scoring games, but the trend leans slightly toward more runs scored overall.

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Sports Handle is home for information on the legal U.S. sports wagering industry — legislation, business, and policy. The team is comprised of veteran journalists who deliver original and investigative reporting, opinion, and analysis of sports betting legislation and regulation at the state and federal levels, plus coverage of the sports betting business landscape. For the latest news, follow along on Twitter at @sports_handle.

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